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Research Groups

Prof Digby Warner

Professor Digby Warner

• Research Interests

o Mycobacterium tuberculosis 
o Molecular mycobacteriology
o Mycobacterial metabolism
o TB transmission TB drug resistance

 

• Publications (NCBI)

Last 5 years, selected (80 original research, review, and commentary articles). 

• de Wet TJ, Winkler KR, Mhlanga MM, Mizrahi V, Warner DF. (2020) Arrayed CRISPRi and quantitative imaging describe the morphotypic landscape of essential mycobacterial genes. bioRxiv 2020.03.20.000372; doi: 10.1101/2020.03.20.000372

• Dinkele R, Gessner R, Koch AS, Morrow C, Gqada M, Kamariza M, Bertozzi CM, Smith B, McLoud C, Kamholz A, Bryden W, Call C, Mizrahi V, Wood R, Warner DF. Capture and visualization of live Mycobacterium tuberculosis bacilli from tuberculosis bioaerosols. (2019) bioRxiv 2019.12.23.887729; doi: 10.1101/2019.12.23.887729

• Omollo C, Singh V, Kigondu E, Wasuna A, Agarwal P, Moosa A, Ioerger TR, Mizrahi V, Chibale V, Warner DF (2019) Developing synergistic drug combinations to restore antibiotic sensitivity in drug-resistant Mycobacterium tuberculosis. bioRxiv 860288; doi:10.1101/860288

• Masuku B, Mkhwanazi N, Young E, Koch A, Warner DF. (2018) Beyond the lab: Eh!woza and knowing tuberculosis. Med Humanit. 44:285-292.

• Egan TJ, Warner DF. (2018) Tuberculosis, malaria and schistosomiasis; understanding resistance and development of new drugs. Curr Opin Pharmacol. 42:iv-vi. doi: 10.1016/j.coph.2018.09.002.

• Beteck RM, Seldon R, Coertzen D, van der Watt ME, Reader J, Mackenzie JS, Lamprecht DA, Abraham M, Eribez K, Müller J, Rui F, Zhu G, Valerio de Grano R, Williams ID, Smit FJ, Steyn AJC, Winzeler EA, Hemphill A, Birkholtz LM, Warner DF, N’Da DD, Haynes RK. (2018) Accessible and distinct decoquinate derivatives active against Mycobacterium tuberculosis and apicomplexan parasites. Communications Chemistry 1, 62 doi:10.1038/s42004-018-0062-7

• Mizrahi V, Warner DF. (2018) Death of Mycobacterium tuberculosis by L-arginine starvation. Proc Natl Acad Sci USA. doi: 10.1073/pnas.1813587115.

• de Wet TJ, Gobe I, Mhlanga MM, Warner DF. (2018) CRISPRi-Seq for the Identification and Characterisation of Essential Mycobacterial Genes and Transcriptional Units. bioRxiv 358275; doi: 10.1101/358275

• Tanner L, Denti P, Wiesner L, Warner DF. (2018) Drug permeation and metabolism in Mycobacterium tuberculosis: prioritising local exposure as essential criterion in new TB drug development. IUBMB Life. doi: 10.1002/iub.1866

• Young E, Masuku B, Toressi B, Warner DF, Koch A. (2018) Eh!woza: Intersection of art and science to engage youth around tuberculosis. Global Health Innovation. In press.

• Reiche MA, Warner DF*, Mizrahi V*. (2017) Targeting DNA Replication and Repair for the Development of Novel Therapeutics against Tuberculosis. Front Mol Biosci. 4:75. doi: 10.3389/fmolb.2017.00075

• Warner DF, Rock JM, Fortune SM, Mizrahi V. (2017) DNA Replication Fidelity in the Mycobacterium tuberculosis Complex. Adv Exp Med Biol. 1019:247-262. doi: 10.1007/978-3-319-64371-7_13

• Moosa A, Lamprecht DA, Arora K, Barry CE 3rd, Boshoff HIM, Ioerger TR, Steyn AJC, Mizrahi V, Warner DF. (2017) Susceptibility of Mycobacterium tuberculosis cytochrome bd oxidase mutants to compounds targeting the terminal respiratory oxidase, cytochrome c. Antimicrob Agents Chemother. doi: 10.1128/AAC.01338-17.

• Ditse Z, Lamers MH, Warner DF. (2017) DNA replication in Mycobacterium tuberculosis. Microbiol Spectrum doi:10.1128/microbiolspec.TBTB2-0027-2016.

• Koch A, Brites D, Stucki D, Evans JC, Seldon R, Heekes A, Mulder N, Nicol M, Oni T, Warner DF, Mizrahi V, Parkhill J, Gagneux S, Martin DP, Wilkinson RJ. (2017) The Influence of HIV on The Evolution of Mycobacterium tuberculosis. Mol Biol Evol. doi: 10.1093/molbev/msx107

• Naran K, Moosa A, Barry CE 3rd, Boshoff HI, Mizrahi V, Warner DF. (2016) Bioluminescent reporters for rapid mechanism of action assessment in tuberculosis drug discovery. Antimicrob Agents Chemother. 2016 Aug 29. pii: AAC.01178-16.r

• Kumar M, Singh K, Naran K, Hamzabegovic F, Hoft DF, Warner DF, Ruminski P, Abate G, Chibale K. (2016) Design, Synthesis, and Evaluation of Novel Hybrid Efflux Pump Inhibitors for Use against Mycobacterium tuberculosis. ACS Infect Dis. 2:714-725.

• Warner DF. (2016) Defining a diagnostic gene signature for tuberculosis. Lancet Respir Med. 4:170-1. doi: 10.1016/S2213-2600(16)00063-1. 

• Wood R, Morrow C, Barry CE 3rd, Bryden WA, Call CJ, Hickey AJ, Rodes CE, Scriba TJ, Blackburn J, Issarow C, Mulder N, Woodward J, Moosa A, Singh V, Mizrahi V, Warner DF. (2016) Real-Time Investigation of Tuberculosis Transmission: Developing the Respiratory Aerosol Sampling Chamber (RASC). PLoS ONE 11:e0146658. doi: 10.1371/journal.pone.0146658.

• Singh V, Brecik M, Mukherjee R, Evans JC, Svetlíková Z, Blaško J, Surade S, Blackburn J, Warner DF, Mikušová K, Mizrahi V. (2015) The complex mechanism of antimycobacterial action of 5-fluorouracil. Chem Biol. doi: 10.1016/j.chembiol.2014.11.006

• Gopinath K, Warner DF, Mizrahi V. (2015) Targeted gene knockout and essentiality testing by homologous recombination. Methods Mol Biol. doi: 10.1007/978-1-4939-2450-9_8